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Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2000 British Association for Psychopharmacology guidelines

Senior Lecturer and Honorary Consultant Psychiatrist, Neuroscience and Psychiatry Unit, University of Manchester, UK, ian.anderson{at}manchester.ac.uk

IN Ferrier

Honorary Consultant Psychiatrist, School of Neurology, Neurobiology and Psychiatry, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK

RC Baldwin

Manchester Mental Health and Social Care Trust, Manchester Royal Infirmary, UK

PJ Cowen

The Psychopharmacology Research Unit, University Department of Psychiatry, Warneford Hospital, Oxford, UK

L Howard

Department, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK

G Lewis

Academic Unit of Psychiatry, Cotham House, Bristol, UK

K Matthews

Section of Psychiatry and Behavioural Sciences, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK

RH McAllister-Williams

Institute of Neuroscience, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK

RC Peveler

University of Southampton, Royal South Hants Hospital, Southampton, UK

J Scott

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK

A Tylee

NIHR Biomedical Research Centre and Health Services and Population Research Department, Institute of Psychiatry, Kings College London, London, UK

A revision of the 2000 British Association for Psychopharmacology evidence-based guidelines for treating depressive disorders with antidepressants was undertaken to incorporate new evidence and to update the recommendations where appropriate. A consensus meeting involving experts in depressive disorders and their management was held in May 2006. Key areas in treating depression were reviewed, and the strength of evidence and clinical implications were considered. The guidelines were drawn up after extensive feedback from participants and interested parties. A literature review is provided, which identifies the quality of evidence to inform the recommendations, the strength of which are based on the level of evidence. These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse, and stopping treatment.

Key Words: antidepressants • depressive disorder • evidence-based guidelines • treatment

This version was published on June 1, 2008

Journal of Psychopharmacology, Vol. 22, No. 4, 343-396 (2008)
DOI: 10.1177/0269881107088441


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