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Lamotrigine treatment of aggression in female borderline patients, Part II: an 18-month follow-up

¹ Clinic for Psychosomatic Medicine and Psychotherapy, Medical University of Graz, Bad Aussee, Austria and University Clinic for Psychiatry 1, PMU, Salzburg, Austria.
² Inntalklink, Simbach am Inn, Germany.
³ Department of Psychosomatic Medicine, University Clinic, Regensburg, Germany
⁴ Psychosomatic Outpatient Clinic, University Medicine Clinic, LMU, Munich, Germany.

^* To whom correspondence should be addressed.

	Abstract

Borderline patients often display pathological aggression. We previously tested lamotrigine, an anti-convulsant, in therapy for aggression in women with borderline personality disorder (BPD) (J Psychopharmacol 2005; 19: 287291), and found significant changes on most scales of the State-Trait Anger Expression Inventory (STAXI) after eight weeks. To assess the longer-term efficacy of lamotrigine in therapy for aggression in women with BPD, this 18-month follow-up observation was carried out, in which patients (treated with lamotrigine: n 5 18; former placebo group: n 5 9) were tested every six months. According to the intent-to-treat principle, significant changes on all scales of the STAXI were observed in the lamotrigine-treated subjects. All subjects tolerated lamotrigine relatively well. Lamotrigine appears to be an effective and relatively safe agent in the longer-term treatment of aggression in women with BPD.

Key Words: borderline personality disorder, aggression, lamotrigine

First published on February 28, 2008, doi:10.1177/0269881107084004

Journal of Psychopharmacology 2008;22:805.

A more recent version of this article appeared on September 1, 2008


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