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Increased cortical inhibition in persons with schizophrenia treated with clozapine

¹ Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
² Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Road Melbourne, Victoria, Australia.
³ Department of Psychiatry, Ernst Moritz Arndt Universität Greifswald, Greifswald, Mecklenburg–Vorpommern, Germany
⁴ Daskalakis Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
⁵ Division of Neurology and Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada.

^* To whom correspondence should be addressed.

	Abstract

Borderline patients often display pathological aggression. We previously tested lamotrigine, an anti–convulsant, in therapy for aggression in women with borderline personality disorder (BPD) (J Psychopharmacol 2005; 19: 287–291), and found significant changes on most scales of the State–Trait Anger Expression Inventory (STAXI) after eight weeks. To assess the longer–term efficacy of lamotrigine in therapy for aggression in women with BPD, this 18–month follow–up observation was carried out, in which patients (treated with lamotrigine: n 5 18; former placebo group: n 5 9) were tested every six months. According to the intent–to–treat principle, significant changes on all scales of the STAXI were observed in the lamotrigine–treated subjects. All subjects tolerated lamotrigine relatively well. Lamotrigine appears to be an effective and relatively safe agent in the longer–term treatment of aggression in women with BPD.

Key Words: borderline personality disorder, aggression, lamotrigine

First published on February 28, 2008, doi:10.1177/0269881107084002

Journal of Psychopharmacology 2008;22:203.

A more recent version of this article appeared on March 1, 2008


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