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An open-label study of citalopram for major depression following traumatic brain injury

¹ Sunnybrook Health Sciences Centre, University of Toronto, FG37-2075 Bayview Avenue,Toronto, Ontario, Canada M4N 3M5
² Sunnybrook Health Sciences Centre, University of Toronto, FG37-2075 Bayview Avenue,Toronto, Ontario, Canada M4N 3M5.

^* To whom correspondence should be addressed.

	Abstract

Major depression is associated with substantial psychosocial dysfunctionand post-concussive symptomatology following traumatic brain injury(TBI). Studies to date of anti-depressant treatment for major depressionpost-TBI have been limited by small sample size. The goal of the presentstudy is to examine the rates of response and remission associated withcitalopram treatment for major depression following traumatic braininjury. Subjects with major depression following mild-to moderate TBIwere treated with open-label citalopram with a starting dose of 20mg/day to a maximum of 50 mg/day for either 6 weeks (n _54) or 10weeks (n _26). The Hamilton Depression Rating Scale (HAMD) wasused to assess depression severity. Response was defined by a 50%reduction in HAMD score, and remission was defined by a HAMDscore of _7. The mean HAMD at baseline and 6 weeks were 23.66(SD 6.8) and 16.30 (SD 9.3), respectively (t[53] _7.157, p _0.0001).The mean HAMD at 10 weeks was 12.96 (SD 7.9) (t[25] _7.323,p _0.0001). At 6 weeks, 54 subjects were assessed and 27.7%responded with 24.1% in remission. At 10 weeks, 26 subjects wereassessed and 46.2% responded with 26.9% in remission. The responserate in the present sample was substantially lower than previouslyreported for patients with TBI, but comparable to the results of thelargest effectiveness trial of citalopram for general out-patients withmajor depression in the absence of TBI.

Key Words: traumatic brain injury, major depression, citalopram, selective serotoninreuptake inhibitors

First published on January 21, 2008, doi:10.1177/0269881107083845

Journal of Psychopharmacology 2008;22:860.

A more recent version of this article appeared on November 1, 2008


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