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Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats
1 School of Pharmacy, University of Bradford, Bradford, West Yorkshire
BD7 1DP, UK.
* To whom correspondence should be addressed.
Gender differences in psychiatric research are becoming more widely recognized, and changes in levels of the steroid hormone, oestrogen, over the menstrual or oestrous cycle are becoming increasingly implicated in alterations in cognitive strategies and capacities. The aim of this study is to investigate the interaction between oestrogen, NMDA receptor function and cognitive processing in rats. Forty-five mature female hooded-Lister rats received vehicle, 0.5, 5 or 10_g/kg of oestradiol benzoate (EB, s.c. in olive oil) 24 h prior to an acute dose of 2mg/kg phencyclidine (PCP, i.p. in 0.9% w/v saline), or vehicle (0.9% saline). After 30 min following PCP treatment, animals completed the novel object recognition task with a 1 min inter-trial interval to assess object recognition memory. Results show that 5 and 10_g/kg of EB 24 h prior to 2mg/kg PCP significantly (P _ 0.01 and _0.001, respectively) protected against the cognitive impairing effect of PCP in contrast to vehicle and 0.5_g/kg EB plus PCP (not significant). EB may exert a neuromodulatory effect in this animal model leading to attenuation of the PCP-induced impairment in object recognition memory, suggesting an interaction between the gonadal steroids and NMDA receptor- mediated cognitive dysfunction, which is of potential relevance to schizophrenia. Key Words: novel object recognition, oestrogen, phencyclidine-PCP, rat, neuroprotection, NMDA receptors, schizophrenia
First published on January 21, 2008, doi:10.1177/0269881107083839 |
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