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Systemic mazindol reduces foodin take in rats via suppression of meal size and meal number

Behavioral Neuroscience Program, Department of Psychology, Texas A&M University, College Station,TX 77843-4235, USA.

^* To whom correspondence should be addressed.

	Abstract

The aim of the present study was to determine the impact of theappetite suppressant mazindol on meal pattern in rats. Meal patternswere monitored in adult male rats after mazindol dosing during the firstthree hours of the dark cycle using automated feeding chambers(BioDAQ). Mazindol (0, 0.25, 1.25 and 2.5 mg/kg, IP) produced a dosedependenthypophagia and hypodipsia. Meal size and meal number weresignificantly suppressed by mazindol. The meal pattern findings indicatethat mazindol inhibits eating in the rat via a suppression of both mealsize and meal number.

Key Words: meal pattern, hypophagia, hypodipsia

First published on January 21, 2008, doi:10.1177/0269881107083837

Journal of Psychopharmacology 2008;22:532.

A more recent version of this article appeared on July 1, 2008


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