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Journal of Psychopharmacology
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0269881107083836v1
22/5/511    most recent
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Article

Comparative effects of the dopaminergic agonists piribedil and bromocriptine in three different memory paradigms in rodents

Aline Marighetto1*, S. Valerio2, J.N. Philippin3, V. Bertaina–Anglade4, C. Drieu La Rochelle4, R. Jaffard3, and P. Morain5

1 Institute of Traditional Medicine, National Yang–Ming University School of Medicine, Taipei, Taiwan.
2 Centre de Neurosciences Intégratives et Cognitives, CNRS UMR 5228, Université de Bordeaux 1, Talence, France
3 Centre de Neurosciences Intégratives et Cognitives, CNRS UMR 5228, Université de Bordeaux 1, Talence, France.
4 Preclinical Pharmacology Department, Biotrial, Rennes, France.
5 Institut de Recherches Internationales SERVIER, Courbevoie, France.

* To whom correspondence should be addressed.


  Abstract

The potential memory–enhancing properties of two dopamine agonists currently used in patients with Parkinson's disease, piribedil (1, 10mg/kg/day, subcutaneously) and bromocriptine (5mg/kg/day, subcutaneously), were evaluated in three experiments. Although piribedil (10mg/kg) and bromocriptine equally enhanced spontaneous object recognition in young adult rats (experiment A), only piribedil displayed beneficial effects against aging–related memory impairments in two radial–maze experiments in mice. First (experiment B), a two–stage paradigm of spatial discrimination was used to assess relational/declarative memory in aged mice; piribedil (1 and 10mg/kg) selectively and significantly improved the performances of aged mice in the critical tests for relational/declarative memory, whereas bromocriptine had no effect. Second, in a novel working memory task (experiment C), vehicle– or bromocriptine–treated aged mice

Key Words: spontaneous object recognition, relational/declarative memory, working memory, rat, mouse, aging

First published on February 28, 2008, doi:10.1177/0269881107083836

Journal of Psychopharmacology 2008;22:511.

A more recent version of this article appeared on July 1, 2008

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