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Journal of Psychopharmacology
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0269881107082905v1
22/7/812    most recent
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Article

Delusional disorder, somatic type treated with aripiprazole-mirtazapine combination

N.P. Dimopoulos1*, Charalambos I. Mitsonis2, and Vassiliki V. Psarra2

1 Psychiatric Clinic, Asklepeion Hospital, Athens, Greece.
2 Psychiatric Hospital of Attiki, Dafni - Medical School, University of Athens, Athens, Greece.

* To whom correspondence should be addressed.


   Abstract

Delusional disorder, somatic type (DDST) is a rare psychiatric disorder and the treatment is mostly based on observations, due to the lack of wellorganized studies. Initially, antipsychotics and especially pimozide were considered to be the pharmacological approach of choice but, subsequently, tryciclic anti-depressants and selective serotonin re-uptake inhibitors (SSRIs) were also suggested to be effective, implicating the serotonergic system in the pathophysiology of the disorder. We present the case of a female with DDST, who responded to aripiprazole-mirtazapine combination, a finding that is in accordance with the initial approach of this disorder as a part of the schizophrenic spectrum, but also supports the hypothesis of serotonin dysfunction in DDST.

Key Words: delusional disorder, somatic type, aripiprazole, mirtazapine

First published on February 28, 2008, doi:10.1177/0269881107082905

Journal of Psychopharmacology 2008;22:812.

A more recent version of this article appeared on September 1, 2008


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