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Ziprasidone and aripiprazole attenuate olanzapine-induced hyperphagia in rats

¹ Bradford School of Pharmacy, University of Bradford, West Yorkshire BD7 1DP, UK.
² Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, Belfast BT9 7BL, UK.

^* To whom correspondence should be addressed.

	Abstract

Weight gain induced by some second-generation anti-psychotics such as olanzapine has emerged as a most debilitating side-effect. This study investigates whether co-administration with either ziprasidone or aripiprazole, which have little propensity to induce weight gain, can attenuate the hyperphagic effect of olanzapine. Female hooded-Lister rats (n _ 8 per group) were treated acutely with either vehicle, olanzapine (1mg/kg), ziprasidone (1mg/kg), aripiprazole (2mg/kg) or olanzapine in combination with ziprasidone or aripiprazole and placed in automated locomotor activity (LMA) boxes with preweighed palatable mash. Food intake and LMA were measured for 60 min postdrug treatment. All olanzapine-treated groups demonstrated significant increases in food intake (P _ 0.001). This effect was attenuated following co-administration of olanzapine with either ziprasidone or aripiprazole (P _ 0.001), neither of which affected food intake alone. The lack of hyperphagia induced by aripiprazole and ziprasidone may reflect an inherent pharmacological mechanism preventing weight gain.

Key Words: antipsychotics, ziprasidone, aripiprazole, olanzapine, hyperphagia, rats

First published on January 21, 2008, doi:10.1177/0269881107081519

Journal of Psychopharmacology 2008;22:567.

A more recent version of this article appeared on July 1, 2008


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