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Differential effects of citalopram andreboxetine on cortical Glx measuredwith proton MR spectroscopy
1 University Department of Psychiatry, Warneford Hospital, Oxford, UK
* To whom correspondence should be addressed.
The pharmacological effects of monoamine potentiating antidepressantsare likely to be expressed ultimately on cortical pyramidal neurones thatuse glutamate as a neurotransmitter. However, there are few data on theeffects of antidepressant treatment on cortical glutamate levels inhumans. The aim of the present study was to use proton magnetic resonancespectroscopy (MRS) to assess the effects of short-term administrationof the selective serotonin re-uptake inhibitor, citalopram and theselective noradrenaline re-uptake inhibitor, reboxetine, on a compositemeasure of glutamate and glutamine (Glx) in occipital cortex in healthyvolunteers using a parallel group, placebo-controlled design. We foundthat relative both to placebo and reboxetine, seven days treatment withcitalopram significantly increased cortical Glx. Our data suggest thatshort-term treatment with citalopram, but not reboxetine, increasesoccipital Glx in healthy subjects. Further studies are needed to find out ifsimilar effects occur in anterior brain regions and whether they reflectchanges in glutamate or glutamine or both.
First published on January 21, 2008, doi:10.1177/0269881107081510 |
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