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Journal of Psychopharmacology
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Article

Effects of acute tiagabine administration on aggressive responses of adult male parolees

Lori M Lieving1*, Don R Cherek2, Scott D Lane3, Oleg V Tcheremissine3, and Sylvain Nouvion3

1 University of Texas-Houston, Health Science Center, USA..
2 University of Texas-Houston, Health Science Center, USA
3 University of Texas-Houston, Health Science Center, USA.

* To whom correspondence should be addressed.


  Abstract

Experimental and clinical studies have supported a relationship between_-aminobutyric acid (GABA) and aggressive behavior in non-humansand humans. Tiagabine is a GABA uptake inhibitor that has been shownto produce acute behavioral effects in animals. In addition, tiagabinehas been shown to decrease aggression in agitated patients whenadministered chronically. The present study was designed to investigatethe effects of acute administration of tiagabine on aggressive respondingon a laboratory task in adult humans. Ten adult males participated inexperimental sessions on the Point Subtraction Aggression Paradigm(PSAP), which provided subjects with aggressive, escape, and monetaryreinforcedresponse options. All subjects received four acute oral doses ofTiagabine (4, 8, 12 and 16mg) separated by placebo sessions. Tiagabinedecreased aggression at doses that either did not affect, or affected toa lesser extent, monetary-reinforced responding. The results are consistentwith some prior research using the PSAP showing a possible uniquerole for GABA in the regulation of human aggression. A possible behavioralmechanism for the rate-decreasing effects on aggressive respondingproduced in the present study is that tiagabine may modify aggressiveresponding by suppressing reactions to aversive stimuli.

Key Words: tiagabine, _-aminobutyric acid, aggression, escape, human

First published on August 22, 2007, doi:10.1177/0269881107078489

Journal of Psychopharmacology 2008;22:144.

A more recent version of this article appeared on March 1, 2008
 This version was published on January 21, 2008
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