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Journal of Psychopharmacology
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0269881106075273v1
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Article

Urticaria and angio-oedema due to ziprasidone

C Akkaya1*, A Sarandol1, K Aydogan2, S Kirli1

1 Uludag University Medical Faculty, Psychiatry Department, Bursa, Turkey.
2 Uludag University Medical Faculty, Dermatology Department, Bursa, Turkey.

* To whom correspondence should be addressed.


  Abstract

Antipsychotic medications are commonly associated with adverse cutaneous reactions (ACRs) in approximately 5% of patients. Angio-oedema accompanying urticaria is one of the most serious ACRs. The 36-year-old female patient who was diagnosed with 'Paranoid schizophrenia' 6 years ago, was commenced on ziprasidone 120 mg/day. On day 30 of the treatment, the patient presented urticarial papules and plaques all over the body and angio-oedema in the face. The patient was diagnosed as 'Urticaria + Angio-oedema'. The development of ACRs after the initation of ziprasidone monotherapy, disappearance of lesions after the discontinuation of this antipsychotic, and positive intradermal skin test all suggests a possible causal relationship between ACRs and ziprasidone. To our knowledge, this is the first reported case of urticaria and angio-oedema due to ziprasidone monotherapy. Ziprasidone is a valid and effective choice amongst antipsychotic medications, but this case calls for caution regarding ACRs at the time of prescribing.

Key Words: ziprasidone;urticaria;angio-oedema

First published on April 19, 2007, doi:10.1177/0269881106075273

Journal of Psychopharmacology 2007;21:550.

A more recent version of this article appeared on July 1, 2007

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