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Journal of Psychopharmacology
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0269881106069467v1
21/4/400    most recent
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Article

Alterations of glucose metabolism during treatment with clozapine or amisulpride: results from a prospective 16-week study

Maria A. Rettenbacher1*, Martina Hummer1, Alex Hofer1, Susanne Baumgartner1, Christoph Ebenbichler2, Monika Edlinger1, Georg Kemmler3, Monika Lechleitner2, W.Wolfgang Fleischhacker4

1 Department of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria
2 Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
3 Department of General Psychiatry, Medical University Innsbruck, Austria
4 Deptartment of Biological Psychiatry, Medical University Innsbruck, Innsbruck, Austria

* To whom correspondence should be addressed.


  Abstract

Although second-generation antipsychotics have notable benefits as compared to typical antipsychotics, their use has been associated with metabolic disturbances, such as alterations of glucose homeostasis. It is still being debated whether this is a class effect of second-generation antipsychotics.

We conducted a prospective, open study comparing body weight, parameters of insulin resistance in schizophrenia patients treated with either clozapine (n = 10) or amisulpride (n = 12). All parameters were assessed monthly over a period of 12 to 16 weeks. Body mass index (BMI), fasting serum insulin levels and the Homeostasis Model Assessment (HOMA) index for insulin resistance increased significantly in patients treated with clozapine. None of these parameters increased significantly in patients treated with amisulpride.

This study indicates that treatment with clozapine appears to have a higher risk to lead to metabolic disturbances than amisulpride.

Key Words: antipsychotics, insulin, weight, glucose metabolism

First published on October 18, 2006, doi:10.1177/0269881106069467

Journal of Psychopharmacology 2007;21:400.

A more recent version of this article appeared on June 1, 2007

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