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Journal of Psychopharmacology
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Article

Reliability of salivary cortisol assessments in cocaine dependent individuals

Helen Fox1*, E. H. Wilker1, M. J. Kreek2, R. Sinha1

1 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
2 Rockefeller University, New York, NY, USA.

* To whom correspondence should be addressed.


   Abstract

The aim of this study was to assess the reliability of salivary cortisol as a measure of hypothalmic-pituitary-adrenal (HPA) axis function in cocaine dependent individuals. Saliva and total plasma samples were collected from 49 abusers on 3 testing days in the morning, across eight time points per day. Significant associations between saliva and plasma cortisol were observed across all time points collapsed across 3 days in both men and women. These moderately significant correlations suggest that salivary measurements represent a stable, non-invasive and broad indicator of HPA axis functioning in cocaine dependent individuals.

Key Words: salivary cortisol, plasma cortisol, cocaine, HPA axis

First published on March 13, 2006, doi:10.1177/0269881106063474

Journal of Psychopharmacology 2006;20:650.

A more recent version of this article appeared on September 1, 2006
This version was published on April 7, 2006


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