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Journal of Psychopharmacology
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0269881106063134v1
20/5/687    most recent
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Article

Methylphenidate for {alpha}-interferon induced depression

Alvaro Camacho* Bernardo Ng

Sun Valley Behavioral Medical Center and Imperial County Behavioral Health Department of Psychiatry, University of California, San Diego, CA, USA.

* To whom correspondence should be addressed.


  Abstract

Interferon-Alpha (IFN) has been effective in the treatment of chronic viral infections and cancer albeit the added risk of severe depression. The literature has reported effectiveness in the use of antidepressants for interferon-induced depression.

We report a case of severe protracted depression induced by IFN in a patient diagnosed with melanoma who responded rapidly to a course of methylphenidate using the Hamilton Depressive Rating Scale.

Methylphenidate appeared to be effective in the treatment of neurovegetative symptoms of major depression induced by IFN. This report provides further clinical evidence that the neurovegetative symptoms of depression might respond better to a norepinephrine uptake inhibitor or psycho-stimulants.

Key Words: methylphenidate, depression, interferon

First published on March 13, 2006, doi:10.1177/0269881106063134

Journal of Psychopharmacology 2006;20:687.

A more recent version of this article appeared on September 1, 2006

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