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0269881105057515v1
20/3/347    most recent
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First published on September 20, 2005, doi:10.1177/0269881105057515

Journal of Psychopharmacology 2006;20:347.

A more recent version of this article appeared on May 1, 2006

Article

Lithium: a review of its metabolic adverse effects

Callum Livingstone1* Hagan Rampes2

1 Consultant Chemical Pathologist, Clinical Biochemistry Department, Royal Surrey County Hospital, Guildford, Surrey, UK.
2 Consultant Psychiatrist, Barnet, Enfield and Haringey Mental Health NHS Trust, Northwest Community Mental Health Team, 7th Floor Premier House, 112 Station Road, Edgware, Middlesex, UK.

* To whom correspondence should be addressed.


  Abstract
Treatment with lithium has long been recognized to be associated with metabolic adverse effects notably hypothyroidism, hyperparathyroidism, weight gain and nephrogenic diabetes insipidus. It is important that clinicians prescribing lithium are aware of these adverse effects and have a strategy for their detection and management. We review aspects of these actions of lithium including their prevalence, risk factors, biochemical changes involved and management, and discuss some advances that have been made in their understanding in recent years.

Key Words: lithium, adverse effects, hypothyroidism, obesity, hyperparathyroidism, diabetes insipidus


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