SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Psychopharmacology
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow All Versions of this Article:
0269881105056996v1
20/1/67    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Khodayar, M. J.
Right arrow Articles by Zarrindast, M.-R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khodayar, M. J.
Right arrow Articles by Zarrindast, M.-R.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CYCLOHEXANOL
*FORMALDEHYDE
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

Antinociceptive effect of spinally administered cannabinergic and {alpha}2-adrenoceptor drugs on the formalin test in rat: possible interactions

Mohammad Javad Khodayar1, Bijan Shafaghi1, Nima Naderi1, Mohammad-Reza Zarrindast2*

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
2 Department of Pharmacology, School of Medicine and Iranian Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran and School of Cognitive Science, Institute Studies in Theoretical Physics and Mathematics, Tehran, Iran.

* To whom correspondence should be addressed.


  Abstract

The current experiments were designed to study the antinociceptive effects of intrathecal (i.t.) administration of cannabinoid CB1 receptor and {alpha}2-adrenoceptor drugs in the nociceptive processing and also their receptor interactions. Different doses of a cannabinoid receptor agonist, CP 55,940, and an {alpha}2-adrenoceptor agonist, clonidine induced a dose-dependent antinociception in both phases of the formalin test.

CP 55,940-induced antinociception was reduced by pretreatment of a selective cannabinoid CB1 receptor antagonist, SR 141716A, but not by pretreatment with an {alpha}2-adrenoceptor antagonist, yohimbine in both phases of the test. However, yohimbine and SR 141716A attenuated the antinociception induced by clonidine in the early phase but not in the late phase of the test. While SR 141716A by itself did not influence pain behaviour, the reversal effect of clonidine by SR 141716A indicate that clonidine stimulate the release of endocannabinoid(s).

In conclusion, our findings may suggest that: (1) spinal cannabinoid and {alpha}2-adrenoceptor systems are able to induce antinociception in both phases of formalin test, and (2) the cannabinoid system may be involved in the antinociception induced by adrenoceptors in the early phase.

Key Words: cannabinoid receptor, {alpha}2-adrenoceptor, antinociception, intrathecal, drug interactions

First published on September 20, 2005, doi:10.1177/0269881105056996

Journal of Psychopharmacology 2006;20:67.

A more recent version of this article appeared on January 1, 2006

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement