SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Journal of Psychopharmacology
This Article
Right arrow Full Text (OnlineFirst PDF)
Right arrow All Versions of this Article:
0269881105056639v1
20/1/47    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Talpos, J. C
Right arrow Articles by Robbins, T. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Talpos, J. C
Right arrow Articles by Robbins, T. W
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Article

A comparison of multiple 5-HT receptors in two tasks measuring impulsivity

John C Talpos1*, Lawrence S Wilkinson2, Trevor W Robbins1

1 Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
2 Laboratory of Cognitive and Behavioural Neuroscience, Babraham Institute, Cambridge, CB2 4AT, UK.

* To whom correspondence should be addressed.


  Abstract
Impulsivity has often been assumed to be a unitary construct. However dissociable forms of impulsive behaviour may exist, each with distinct neurochemical underpinnings. To test this hypothesis, behavioural effects of three partially selective serotonergic (5-HT) ligands, ketanserin (5-HT2A,C receptor antagonist), SER-082 (5-HT2C,Breceptor antagonist) and SB-270146-A (5-HT6 receptor antagonist) were compared in two tests of impulsivity. The five-choice serial reaction time task (5-csrtt) and a delayed reward task were chosen as they measure theoretically different types of impulsivity, behavioural inhibition versus choice preference for a delayed reward. Dissociation was seen between the effects of ketanserin, which decreased impulsivity in the 5-csrtt, but had no effect on the delayed reward task, and SER-082, which had no effect on the 5-csrtt, but decreased impulsive responding in the delayed reward task. SB-270146-A had no effect in either paradigm. The results suggest that the 5-csrtt and the delayed reward task do in fact measure different types of impulsive behaviour, which are at least partially neurochemically distinct.

Key Words: impulsivity, attention, delayed reward, 5-csrtt, 5-HT2a, 5-HT2c, 5-HT6, behavioural inhibition, ADHD

First published on October 4, 2005, doi:10.1177/0269881105056639

Journal of Psychopharmacology 2006;20:47.

A more recent version of this article appeared on January 1, 2006

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
C. M. Doe, D. Relkovic, A. S. Garfield, J. W. Dalley, D. E.H. Theobald, T. Humby, L. S. Wilkinson, and A. R. Isles
Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour
Hum. Mol. Genet., June 15, 2009; 18(12): 2140 - 2148.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. A. Ardayfio, M. J. Benvenga, S. F. Chaney, P. L. Love, J. Catlow, S. P. Swanson, and G. J. Marek
The 5-Hydroxytryptamine2A Receptor Antagonist R-(+)-{alpha}-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat
J. Pharmacol. Exp. Ther., December 1, 2008; 327(3): 891 - 897.
[Abstract] [Full Text] [PDF]


Advertisement