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Chronic citalopram treatment does not sensitize the adrenal gland to ACTH (1—24) in rats

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK

J.D. Leggett

Department of Anatomy, University of Bristol, Bristol, UK

D.S. Jessop Henry

Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK, david.jessop{at}bristol.ac.uk

We have previously reported that rats exposed chronically to citalopram are able to elicit a corticosterone but not adrenocorticotropic hormone (ACTH) response to restraint stress. Thus we proposed the hypothesis that the corticosterone response to restraint in citalopram-treated rats was maintained due to increased adrenal sensitivity to lower ACTH levels. To test this hypothesis, we intravenously injected ACTH (1—24) to rats (dose 3 ng/rat) exposed to citalopram through minipump infusion for 14 days and to control rats (no citalopram). ACTH significantly increased plasma corticosterone levels in both control and citalopram treated rats over a period of 120 min. There was no significant difference in plasma corticosterone between citalopram treated rats and control rats at any time point. Therefore we conclude that, under these experimental conditions, citalopram does not appear to sensitize the rodent adrenal gland to ACTH, and that other mechanisms may be responsible for the ACTH/corticosterone disconnection.

Key Words: SSRI • citalopram • ACTH • corticosterone • rat

References

• Bornstein S.R., Chrousos G.P. (1999) Adrenocorticotrophin (ACTH) - and non-ACTH-mediated regulation of the adrenal cortex: Neural and Immune imputs. J Clin Endocrinol Metab 84: 1729—1736[Free Full Text]
• Boyle M.P., Brewer J.A., Funatsu M., Wozniak D.F., Tsien J.Z., Izumi Y., Muglia L.J. (2005) Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behaviour. Proc Natl Acad Sci 102: 473—478[Abstract/Free Full Text]
• Dallman M.F., Akana S.F., Levin N., Walker C.D., Bradbury M.J., Suemaru S., Scribner K.S. (1994) Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis. Ann N Y Acad Sci 746: 22—31[Web of Science][Medline] [Order article via Infotrieve]
• Davis L., Yonkers K., Trivedi M., Kramer G., Petty F. (1999) The mechanism of action of SSRI's: a new hypothesis. In Stanford S C (ed.), Selective serotonin reuptake inhibitors: Past present and future. University College, London
• Harbuz M.S., Rees R.G., Eckland D., Jessop D.S., Brewerton D., Lightman S.L. (1992) Paradoxical responses of hypothalamic corticotropin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRF-41 peptide and adenohypophysial proopiomelanocortin mRNA during chronic inflammatory stress. Endocrinology 130: 1394—1400[Abstract/Free Full Text]
• Harbuz M.S., Rooney C., Jones M. and Ingram C.D. (1994) Hypothalamo-pituitary-adrenal axis response to lipopolysaccharide in male and female rats with adjuvant-induced arthritis. Brain Behav Immun 13: 335—347[CrossRef]
• Hesketh S., Jessop D.S., Hogg S., Harbuz M.S. (2005) Differential actions of acute and chronic citalopram on the rodent hypothalamic-pituitary-adrenal axis response to acute restraint stress. J Endocrinol 185: 373—382[Abstract/Free Full Text]
• Jacobson L., Sapolsky R. (1991) The role of the hippocampus in feedback regulation of hypothalamic-pituitary-adrenocortical axis. Endocr Rev 12: 118—134[Abstract/Free Full Text]
• Jensen J., Jessop D., Harbuz M., Mork A., Sanchez C., Mikkelsen J. (1999) Acute and long-term treatments with the selective serotonin inhibitor citalopram modulates the HPA axis activity at different levels in male rats. J Neuroendocrinol 11: 465—471[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Jensen J., Mork A., Mikkelsen J. (2001) Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: Effects of acute stress and 5HT1A receptor activation. J Neuroendocrinol 13: 887—893[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Larsen P.J., Mikkelsen J.D., Jessop D., Lightman S.L., Chowdrey H.S. (1994). Neonatal monosodium glutamate treatment alters both the activity and the sensitivity of the rat hypothalamo-pituitary-adrenocortical axis. J Endocrinol 141: 497—503[Abstract/Free Full Text]
• Leggett J.D., Harbuz M.S., Jessop D.S., Fulford A.J. (2006). The nociceptin receptor antagonist [Nphe1,Arg14,Lys15]nociceptin/orphanin FQ-NH2 blocks the stimulatory effects of nociceptin/orphanin FQ on the HPA axis in rats. Neuroscience 141: 2051—2057[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Maes M., Meltzer Y., D'Hondt P., Cosyns P., Blockx P. (1995) Effects of serotonin precursors on the negative feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal axis function in depression. Psychoneuroendocrinology 20: 149—167[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Masand P., Gupta S. (1999) Selective serotonin reuptake inhibitors: An update. Harvard Rev Psychiatry 7: 69—84[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Moncek F., Duncko R., Jezova D. (2003). Repeated citalopram treatment but not stress exposure attenuates hypothalamic-pituitary-adrenocortical axis response to acute citalopram injection. Life Sci 72: 1353—1365[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Nemeroff C., Winderlov E., Bissette G., Walleus H., Karlsson I., Eklund K., Kilts C., Loosen P., Vale W. ( 1984) Elevated concentration of CSF CRF immunoreactivity in depressed patients. Science 226: 1342—1344[Abstract/Free Full Text]
• Pariante C.M. (2004) Glucocorticoid receptor functions in vitro in patients with major depression. Stress 7: 209—219[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Raap D., Van de Kar L (1999) Selective serotonin re-uptake inhibitors and neuroendocrine function. Life Sci 65: 1217—1235[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Sage D., Maurel D., Bosler O. (2002) Corticosterone-dependent driving influence of the suprachiasmatic nucleus on adrenal sensitivity to ACTH. Am J Physiol Endocrinol Metab 282: E458—E465[Abstract/Free Full Text]
• Schinner S., Bornstein S.R. (2005) Cortical-chromaffin cell interactions in the adrenal gland. Endocr Pathol 16: 91—98[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
• Schroeter S., Levey A I., Blakely R.D. (1997) Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Mol Cel Neurosc 9: 170—184[CrossRef]
• Young E., Haskett R., Murphy-Weinberg V., Watson S., Akil H. ( 1991) Loss of fast-feedback in depression. Arch Gen Psychiatry 48: 693—699[Abstract/Free Full Text]

This version was published on November 1, 2007

Journal of Psychopharmacology, Vol. 21, No. 8, 885-887 (2007)
DOI: 10.1177/0269881107078310


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hesketh, S.A. Articles by Jessop Henry, D.S. Search for Related Content PubMed PubMed Citation Articles by Hesketh, S.A. Articles by Jessop Henry, D.S. Social Bookmarking                         What's this?