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Pregabalin in the treatment of depression

Community Psychiatrists Association of Toronto, Ontario, Canada, communitypsychiatrists{at}sympatico.ca

Although studies have demonstrated the efficacy of the new anti-epileptic on the block, Pregabalin, in the treatment of Generalized Anxiety Disorder and Social Anxiety Disorder, there is no study so far of such efficacy for the treatment of depression. This case study in a patient with chronic major depression demonstrates that Pregabalin could be an effective augmenting agent to other anti-depressants, e.g. SSRI's and SNRI's. This added property of Pregabalin may be related to its probable GABA-ergic mechanism of action that could be soon the emerging treatment pathway for achieving better remission in chronic depression that is yet clinically problematic.

Key Words: Pregabalin • depression • augmentation • anxiety • GABA

References

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• Pande A.C., Crockatt J.G., Feltner D.E., Janney C.A., Smith W.T., Weisler R., Londborg P.D., Bielski R.J., Zimbroff D.L., Davidson J.R., Liu-Dumaw M. (2003) Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 160: 533—540[Abstract/Free Full Text]
• Pande A.C., Feltner D.E., Jefferson J.W., Davidson J.R., Pollack M., Stein M.B., Lydiard R.B., Futterer R., Robinson P., Slomkowski M., DuBoff E., Phelps M., Janney C.A., Werth J.L. (2004) Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. J Clin Psychopharmacol 24: 141—149[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
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Journal of Psychopharmacology, Vol. 21, No. 8, 883-884 (2007)
DOI: 10.1177/0269881107078496


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Showraki, M. Search for Related Content PubMed PubMed Citation Articles by Showraki, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Depression Social Bookmarking                         What's this?