Journal of Psychopharmacology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

SAGETRACK

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oranje, B.
Right arrow Articles by Kahn, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oranje, B.
Right arrow Articles by Kahn, R. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
This version was published on November 1, 2006
Journal of Psychopharmacology, Vol. 20, No. 6, 789-798 (2006)
DOI: 10.1177/0269881106061712

No effects of l-dopa and bromocriptine on psychophysiological parameters of human selective attention

B. Oranje

Centre for Neuropsychiatric Schizophrenia Research, Department of Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark

C. C. Gispen-de Wied

H. G. M. Westenberg

C. Kemner

Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands

M. N. Verbaten

Faculty of Pharmaceutical Sciences, Department of Psychopharmacology, Utrecht University, Utrecht, The Netherlands

R. S. Kahn

Department of Psychiatry, University Medical Centre, Utrecht, The Netherlands

Patients with schizophrenia exhibit diverse cognitive deficits, one of which is a loss of the ability to focus attention. According to the revised dopamine hypothesis of schizophrenia both an increased mesolimbic and a decreased prefrontal dopaminergic activity is suggested to be involved in schizophrenia. The current study was designed to explore the relationship between dopamine and two psychophysiological parameters of selective attention, i.e. P300 amplitude and processing negativity (PN) in healthy volunteers.

In two separate experiments, with a double-blind, balanced and placebo-controlled crossover design, 18 healthy male volunteers were orally administered either 300mg l-dopa (precursor of dopamine) or placebo (experiment I), or 1.25mg bromocriptine (D2 agonist) or placebo (experiment II). Following this treatment they were tested in an auditory, dichotic selective attention paradigm.

An increase in P300 amplitude was found following deviant stimuli when compared to standard stimuli and following attended stimuli when compared to unattended stimuli, regardless of treatment. Similarly, PN was found regardless of treatment. Neither l-dopa nor bromocriptine affected task performance or the amplitudes of PN or P300.

In the present study neither l-dopa nor bromocriptine affected PN, P300 amplitude or task performance in healthy controls, phenomena which are usually found to be disrupted in schizophrenia. This indicates that P300 amplitude and PN are neither affected by a global (l-dopa) increased dopaminergic activity, nor by a more selectively towards striatal areas targeted (bromocriptine) increase in dopaminergic activity.

Key Words: dopamine • l-dopa • bromocriptine • selective attention • P300 • processing negativity • auditory oddball task

References

  • Abduljawad K A, Langley R W, Bradshaw C M, Szabadi E (1998) Effects of bromocriptine and haloperidol on prepulse inhibition of the acoustic startle response in man . J Psychopharmacol 12: 239–245 [Abstract/Free Full Text]
  • Abduljawad K A, Langley R W, Bradshaw C M, Szabadi E (1999) Effects of bromocriptine and haloperidol on prepulse inhibition: comparison of the acoustic startle eyeblink response and the N1/P2 auditory-evoked response in man . J Psychopharmacol 13: 3–9 [Abstract]
  • Ahveninen J, Jaaskelainen I P, Pennanen S, Liesivuori J, Ilmoniemi R J, Kahkonen S (2003) Auditory selective attention modulated by tryptophan depletion in humans . Neurosci Lett 340: 181–184 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Andreasen N C, Flaum M, Arndt S (1992) The comprehensive assessment of symptoms and history (CASH): an instrument for assessing psychopathology and diagnosis . Arch Gen Psychiatry 49: 615–623 [Abstract]
  • Antal A, Keri S, Bodis-Wollner I (1997) Dopamine D2 receptor blockade alters the primary and cognitive components of visual evoked potentials in the monkey, Macaca fascicularis . Neurosci Lett 232: 179–181 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Baribeau-Braun J, Picton T W, Gosselin J Y (1983) Schizophrenia: a neurophysiological evaluation of abnormal information processing . Science 219: 874–876 [Abstract/Free Full Text]
  • Boutros N N, Nasrallah H, Leighty R, Torello M (1997) Auditory evoked potentials, clinical vs research applications . Psychiatry Res 69: 183–195 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Cedarbaum J M, Kutt H, McDowell F H (1989) A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100) . Neurology 39: 38–44 [ISI][Medline] [Order article via Infotrieve]
  • Clark C R, Geffen G M, Geffen L B (1987) Catecholamines and attention: II. Pharmacological studies in normal humans . Neurosci Biobehav Rev 11: 353–364 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Coburn K L, Shillcutt S D, Tucker K A, Estes K M, Brin F B, Merai P, Moore N C (1998) P300 delay and attenuation in schizophrenia: reversal by neuroleptic medication . Biol Psychiatry 44: 466–474 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • del Pozo E, Schluter K, Nuesch E, Rosenthaler J, Kerp L (1986) Pharmacokinetics of a long-acting bromocriptine preparation (Parlodel LA) and its effect on release of prolactin and growth hormone . Eur J Clin Pharmacol 29: 615–618 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Dempski R E, Scholtz E C, Oberholtzer E R, Yeh K C (1989) Pharmaceutical design and development of a Sinemet controlled-release formulation . Neurology 39: 20–24 [ISI][Medline] [Order article via Infotrieve]
  • Drewe J, Mazer N, Abisch E, Krummen K, Keck M (1988) Differential effect of food on kinetics of bromocriptine in a modified release capsule and a conventional formulation . Eur J Clin Pharmacol 35: 535–541 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Duncan G E, Sheitman B B, Lieberman J A (1999) An integrated view of pathophysiological models of schizophrenia . Brain Res Brain Res Rev 29: 250–264 [CrossRef][Medline] [Order article via Infotrieve]
  • Endicott J, Spitzer R L (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia . Arch Gen Psychiatry 35: 837–844 [Abstract]
  • Frazer A E, Molinoff P B E, Winokur A E (1994) Biological Bases of Brain Function and Disease. Raven Press, New York, NY
  • Friedman D (1991) Endogenous scalp-recorded brain potentials in schizophrenia: a methodological review. In Steinhauer S R, Gruzelier J H, Zubin J (eds), Neuropsychology, Psychophysiology, and Information Processing. Elsevier Science Publishing Co., Amsterdam , pp. 91–127
  • Frodl Bauch T, Bottlender R, Hegerl U (1999a) Neurochemical substrates and neuroanatomical generators of the event-related P300 . Neuropsychobiology 40: 86–94 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Frodl Bauch T, Gallinat J, Meisenzahl E M, Moller H J, Hegerl U (1999b) P300 subcomponents reflect different aspects of psychopathology in schizophrenia . Biol Psychiatry 45: 116–126 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Green M F (1998) Schizophrenia from a Neurocognitive Perspective: Probing the Impenetrable Darkness. Allyn and Bacon, Inc., Boston, MA , pp. xii-xii, 190-190.
  • Iwanami A, Isono H, Okajima Y, Noda Y, Kamijima K (1998) Eventrelated potentials during a selective attention task with short interstimulus intervals in patients with schizophrenia . J Psychiatry Neurosci 23: 45–50 [ISI][Medline] [Order article via Infotrieve]
  • Javitt D C, Doneshka P, Grochowski S, Ritter W (1995) Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia . Arch Gen Psychiatry 52: 550–558 [Abstract]
  • Jeon Y W, Polich J (2003) Meta-analysis of P300 and schizophrenia: patients, paradigms, and practical implications . Psychophysiology 40: 684–701 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Jonkman L M, Kemner C, Verbaten M N, Koelega H S, Camfferman G, Gaag R J v d, Buitelaar J K, van Engeland H (1997) Event-related potentials and performance of Attention-Deficit Hyperactivity Disorder: children and normal controls in auditory and visual selective attention tasks . Biol Psychiatry 41: 595–611 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Juckel G, Mullerschubert A, Gaebel W, Hegerl U (1996) Residual symptoms and P300 in schizophrenic outpatients . Psychiatry Res 65: 23–32 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Kahkonen S, Ahveninen J, Jaaskelainen I P, Kaakkola S, Näätänen R, Huttunen J, Pekkonen E (2001) Effects of haloperidol on selective attention: a combined whole-head MEG and high-resolution EEG study . Neuropsychopharmacology 25: 498–504 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Kahn R S, Davidson M (1995) Dopamine in schizophrenia. In den Boer J A, Westenberg H G M, van Praag H M (eds), Advances in the Neurobiology of Schizophrenia: Wiley & Sons Ltd, New York , pp. 204–220
  • Karoumi B, Laurent A, Rosenfeld F, Rochet T, Brunon A M, Dalery J (2000) Alteration of event related potentials in siblings discordant for schizophrenia . Schizophr Res 41: 325–334 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Kayser J, Bruder G E, Tenke C E, Stuart B K, Amador X F, Gorman J M (2001) Event-related brain potentials (ERPs) in schizophrenia for tonal and phonetic oddball tasks . Biol Psychiatry 49: 832–847 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Kenemans J L, Molenaar P C, Verbaten M N, Slangen J L (1991) Removal of the ocular artifact from the EEG: a comparison of time and frequency domain methods with simulated and real data . Psychophysiology 28: 114–121 [ISI][Medline] [Order article via Infotrieve]
  • Kopitar Z, Vrhovac B, Povsic L, Plavsic F, Francetic I, Urbancic J (1991) The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine . Eur J Drug Metab Pharmacokinet 16: 177–181 [ISI][Medline] [Order article via Infotrieve]
  • Kraepelin E (1913) Psychiatrie, ein Lehrbuch für Studierende und Ärzte, 8th edn. Barth, J.A., Leipzig
  • Kruk Z L, Pycock C J (1991) Neurotransmitters and drugs, 3rd ed. Chapman and Hall, London
  • Laruelle M, Kegeles L S, Abi-Dargham A (2003) Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment . Annals New York Academy of Sciences 1003: 138–158 [Abstract/Free Full Text]
  • LeWitt P A, Nelson M V, Berchou R C, Galloway M P, Kesaree N, Kareti D, Schlick P (1989) Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies . Neurology 39: 45–53 [ISI][Medline] [Order article via Infotrieve]
  • Luthringer R, Rinaudo G, Toussaint M, Bailey P, Muller G, Muzet A, Macher J (1999) Electroencephalographic characterization of brain dopaminergic stimulation by apomorphine in healthy volunteers . Neuropsychobiology 39: 49–56 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • McGhie A, Chapman J (1961) Disorders of attention and perception in early schizophrenia . Brit J Med Psychol 34: 103–116 [ISI][Medline] [Order article via Infotrieve]
  • McKetin R, Ward P B, Catts S V, Mattick R P, Bell J R (1999) Changes in auditory selective attention and event-related potentials following oral administration of D-amphetamine in humans . Neuropsychopharmacology 21: 380–390 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Mervaala E, Alhainen K, Helkala E L, Partanen J, Jousmaki V, Vayrynen M, Heinonen E, Riekkinen P (1993) Electrophysiological and neuropsychological effects of a central alpha 2-antagonist atipamezole in healthy volunteers . Behav Brain Res 55: 85–91 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Michie P T, Fox A M, Ward P B, Catts S V, Mcconaghy N (1990) Eventrelated potential indices of selective attention and cortical lateralization in schizophrenia . Psychophysiology 27: 209–227 [ISI][Medline] [Order article via Infotrieve]
  • Muller T J, Kalus P, Strik W K (2001) The neurophysiological meaning of auditory P300 in subtypes of schizophrenia . World J Biol Psychiatry 2: 9–17 [Medline] [Order article via Infotrieve]
  • Munson P L, Mueller R A, Breese G R (1995) Principles of Pharmacology, Basic Concepts and Clinical Applications. Chapman and Hall, New York
  • Näätänen R (1990) The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function . Behav Brain Sci 13: 201–288 [ISI]
  • Nieoullon A (2002) Dopamine and the regulation of cognition and attention . Prog Neurobiol 67: 53–83 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Nishimura N, Ogura C, Ohta I (1995) Effects of the dopamine-related drug bromocriptine on event-related potentials and its relation to the law of initial value . Psychiatry Clin Neurosci 49: 79–86 [Medline] [Order article via Infotrieve]
  • Oishi M, Mochizuki Y, Hara M, Du C M, Takasu T (1996) Effects of intravenous L-dopa on P300 and regional cerebral blood flow in parkinsonism . Int J Neurosci 85: 147–154 [ISI][Medline] [Order article via Infotrieve]
  • Oranje B, Gispen-de Wied C C, Verbaten M N, Kahn R S (submitted) The effects of ketamine and haloperidol on human selective attention
  • Oranje B, Gispen-de Wied C C, Verbaten M N, Kahn R S (2004) Increasing dopaminergic activity in humans: effects of l-dopa and bromocriptine on human sensory gating . J Psychopharmacol 18: 388–394 [Abstract]
  • Oranje B, van Berckel B N M, Kemner C, van Ree J M, Kahn R S, Verbaten M N (2000) The effects of a sub-anaesthetic dose of ketamine on human selective attention . Neuropsychopharmacology 22: 293–302 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Robertson D R, Higginson I, Macklin B S, Renwick A G, Waller D G, George C F (1991) The influence of protein containing meals on the pharmacokinetics of levodopa in healthy volunteers . Br J Clin Pharmacol 31: 413–417 [ISI][Medline] [Order article via Infotrieve]
  • Roth W T, Cannon E H (1972) Some features of the auditory evoked response in schizophrenics . Arch Gen Psychiatry 27: 466–471 [ISI][Medline] [Order article via Infotrieve]
  • Sevostianov A, Fromm S, Nechaev V, Horwitz B, Braun A (2002) Effect of attention on central auditory processing: an fMRI study . Int J Neurosci 112: 587–606 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Shelley A M, Catts S V, Ward P B, Andrews S, Mitchell P, Michie P, Mcconaghy N (1997) The effect of decreased catecholamine transmission on ERP indices of selective attention . Neuropsychopharmacology 16: 202–210 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Shutara Y, Koga Y, Fujita K, Takeuchi H, Mochida M, Takemasa K (1996) An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia . Brain Topogr 8: 285–289 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Strandburg R J, Marsh J T, Brown W S, Asarnow R F, Guthrie D, Harper R, Nuechterlein K H (1999) Continuous-processing related ERPs in adult schizophrenia: continuity with childhood onset schizophrenia . Biol Psychiatry 45: 1356–1369 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Strik W K, Dierks T, Kulke H, Maurer K, Fallgatter A (1996) The predictive value of P300-amplitudes in the course of schizophrenic disorders . J Neural Transm 103: 1351–1359 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Takeshita S, Ogura C (1994) Effect of the dopamine D2 antagonist sulpiride on event-related potentials and its relation to the law of initial value . Int J Psychophysiol 16: 99–106 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Tandon R, Milner K, Jibson M D (1999) Antipsychotics from theory to practice: integrating clinical and basic data . J Clin Psychiatry 60(Suppl. 8): 21–28
  • Umbricht D, Javitt D, Novak G, Bates J, Pollack S, Lieberman J, Kane J (1998) Effects of clozapine on auditory event-related potentials in schizophrenia . Biol Psychiatry 44: 716–725 [CrossRef][ISI][Medline] [Order article via Infotrieve]
  • Ward P B, Catts S V, Fox A M, Michie P T, Mcconaghy N (1991) Auditory selective attention and event-related potentials in schizophrenia . Br J Psychiatry 158: 534–539 [Abstract/Free Full Text]
  • Woods D L (1990) The physiological basis of selective attention: implications of event-related potential studies. In Rohrbaugh J W, Parasuraman R, Johnson R Jr (eds), Event-related Brain Potentials: Basic Issues and Applications. Oxford University Press, New York , pp. 178–209
  • Yeh K C, August T F, Bush D F, Lasseter K C, Musson D G, Schwartz S, Smith M E, Titus D C (1989) Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies . Neurology 39: 25–38 [Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?



This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oranje, B.
Right arrow Articles by Kahn, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oranje, B.
Right arrow Articles by Kahn, R. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?