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Journal of Psychopharmacology
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Central benzodiazepine receptor imaging and quantitation with single photon emission computerised tomography: SPECT

Chike I. Okocha

Clinical Psychopharmacology Section (MRC), Institute of Psychiatry, De Crespigny Park Denmark Hill, London SE5 8AF, UK

Flavio Kapczinski

Clinical Psychopharmacology Section (MRC), Institute of Psychiatry, De Crespigny Park Denmark Hill, London SE5 8AF, UK

Niels Lassen

Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark

Malcolm H. Lader

Clinical Psychopharmacology Section (MRC), Institute of Psychiatry, De Crespigny Park Denmark Hill, London SE5 8AF, UK

This review discusses the current use of single photon emission computerised tomography (SPECT) for central benzodiazepine receptor imaging and quantitation. The general principles underlying SPECT imaging and receptor quantitation methods such as the kinetic, pseudo-equilibrium and steady-state (tracer infusion and bolus) approaches are described. The advantages and practical drawbacks of these techniques are highlighted.

Key Words: SPECT • benzodiazepine receptors • [123I]iomazenil • receptor quantitation • review

Journal of Psychopharmacology, Vol. 9, No. 4, 369-380 (1995)
DOI: 10.1177/026988119500900412
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