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Journal of Psychopharmacology, Vol. 9, No. 4, 331-335 (1995)
DOI: 10.1177/026988119500900407

Buspirone treatment as an aid to benzodiazepine withdrawal

S. Morton

Institute of Psychiatry, University of London, London SE5 8AF, UK

M. Lader

Institute of Psychiatry, University of London, London SE5 8AF, UK

Twenty four long-term benzodiazepine users were allocated randomly to treatment with either buspirone (mean dose 25 mg/day) or placebo, prior to tapering off the benzodiazepine over 6 weeks. In both groups, six out of 12 patients successfully completed withdrawal. However, buspirone-treated patients tended to have lower anxiety levels than placebo-treated patients. The amount of previous benzodiazepine usage predicted outcome.

Key Words: benzodiazepines • dependence • buspirone • anxiety


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