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Journal of Psychopharmacology
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Menstrual cycle effects on the action of buspirone on food intake in healthy female volunteers

E.M. Goodall

Formerly Academic Unit of Human Psychopharmacology, Department of Psychological Medicine, Medical College of St Bartholomew's Hospital, London EC1A 7BE, Psychopharmacology Research Unit, Littlemore Hospital, Oxford OX4 4XN, UK

M. Whittle

Academic Unit of Human Psychopharmacology, Royal London Hospital, St Clements, London E3 4LL

J. Cookson

Academic Unit of Human Psychopharmacology, Royal London Hospital, St Clements, London E3 4LL

P.J. Cowen

Psychopharmacology Research Unit, Littlemore Hospital, Oxford OX4 4XN, UK

T. Silverstone

Formerly Academic Unit of Human Psychopharmacology, Department of Psychological Medicine, Medical College of St Bartholomew's Hospital, London EC1A 7BE, Department of Psychological Medicine, University of Otago, New Zealand

We studied the effect of single doses of the 5-HT1A agonist buspirone (10 mg and 20 mg) on food intake during the menstrual cycle of nine healthy women, none of whom were on a contraceptive pill. In a double-blind placebo-controlled trial, subjects were tested over three cycles, receiving one treatment per cycle. Within each cycle, they were tested at two time points; mid-follicular and late luteal. Food intake following 20 mg buspirone was significantly higher in the luteal phase, suggesting the possibility of pre-menstrually enhanced 5-HT receptor sensitivity.

Key Words: buspirone • 5-HT • food intake • menstrual cycle • luteal phase • pre-menstrual symptoms

Journal of Psychopharmacology, Vol. 9, No. 4, 307-312 (1995)
DOI: 10.1177/026988119500900403
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