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Serotonergic drug effects on a delayed conditional discrimination task in the rat; involvement of the 5-HT1A receptor in working memory

Utrecht University, Rudolf Magnus Institute of Neuroscience, Faculty of Pharmacy, Department of Psychopharmacology, PO Box 80082, 3508 TB, Utrecht, The Netherlands

Theo H. Hijzen

Utrecht University, Rudolf Magnus Institute of Neuroscience, Faculty of Pharmacy, Department of Psychopharmacology, PO Box 80082, 3508 TB, Utrecht, The Netherlands

Berend Olivier

Utrecht University, Rudolf Magnus Institute of Neuroscience, Faculty of Pharmacy, Department of Psychopharmacology, PO Box 80082, 3508 TB, Utrecht, The Netherlands

Jef L. Slangen

Utrecht University, Rudolf Magnus Institute of Neuroscience, Faculty of Pharmacy, Department of Psychopharmacology, PO Box 80082, 3508 TB, Utrecht, The Netherlands

We investigated the effects of serotonergic drugs on working memory (WM) in a delayed conditional discrimination task. The 5-HT_1A receptor full agonist flesinoxan (0.3-3.0 mg/kg) dose- and delay-dependently impaired performance, indicating a specific effect on WM. The 5-HT_1A receptor partial agonist ipsapirone, the 5-HT _1B/1D/2C agonist TFMPP, the 5-HT_1A antagonist NAN190 and the serotonin re-uptake inhibitor fluvoxamine dose-dependently impaired performance, in a delay-independent manner, indicating no specific effect on WM. The 5-HT ₂ receptor antagonist ketanserin and the 5-HT₃ receptor antagonist ondansetron did not affect performance. It is suggested that the role of central serotonin receptors in WM may be restricted to 5-HT_1A receptors.

Key Words: serotonin • agonists • antagonists • 5-HT1A • flesinoxan • fluvoxamine • ipsapirone • ketanserin • NAN190; ondansetron • TFMPP • working memory • delayed conditional discrimination • rats

Journal of Psychopharmacology, Vol. 9, No. 3, 242-250 (1995)
DOI: 10.1177/026988119500900307


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