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Effects of ritanserin and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) in the murine elevated plus-maze test of anxiety: an ethopharmacological study

Ethopharmacology Laboratory, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK

N.J.T. Johnson

Ethopharmacology Laboratory, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK

S.J. Norton

Ethopharmacology Laboratory, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK

J.C. Cole

Ethopharmacology Laboratory, Department of Psychology, University of Leeds, Leeds LS2 9JT, UK

The 5-HT_2A/2c receptor antagonist, ritanserin, has produced highly variable results in animal models of anxiety. The present study addressed the effects of this compound (0.5-5.0 mg/kg) and those of the 5-HT_2A/2C receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (0.25-1.0 mg/kg), in an ethological version of the murine elevated plus-maze paradigm. In marked contrast to the potent effects produced by other compounds (anxiolytic and anxiogenic) under identical test conditions, results show that, over the dose ranges tested, neither compound significantly altered behavioural profiles. Findings are discussed in relation to the question of receptor affinities and the need for studies on compounds with more selective profiles of action.

Key Words: elevated plus-maze • anxiety • defence • risk assessment • ritanserin • DOI • 5-HT • mice

Journal of Psychopharmacology, Vol. 9, No. 1, 38-42 (1995)
DOI: 10.1177/026988119500900107


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