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Amnesia following gastroscopy with midazolam: a comparison in two age groupsDepartment of Psychiatry, Clinical School, 43 Collins Street, Hobart 7000
Department of Psychology, University of Tasmania, PO Box 252C, Hobart 7001, Tasmania, Australia
Department of Psychology, University of Tasmania, PO Box 252C, Hobart 7001, Tasmania, Australia
Department of Psychology, University of Tasmania, PO Box 252C, Hobart 7001, Tasmania, Australia Forty patients, in two age groups, undergoing gastroscopy, received intravenous midazolam as the sole pre- medication. Mean ages were 35 (range 19-47) and 65.5 (range 53-75) and mean dosages 4.52 and 5.82 mg, respectively in the two groups. Neuropsychological testing pre- and post-medication comprised the Rey auditory verbal learning test (RAVLT), word association test, digit span and face memory test. The elderly group gave significantly more false-positive responses on recognition recall on the RAVLT and had significant impairment of reverse digit span. Following midazolam, in both age groups there was a significantly reduced rate of verbal learning and a marked deficit in delayed free recall coupled with substantial preservation of recognition recall. Word fluency and forward digit span were not affected. There was an increase in false-positive responses for face memory. These findings are consistent with a specific processing deficit affecting the acquisition of episodic long-term memory.
Key Words: midazolam • benzodiazepine • amnesia • neuropsychological tests • aging
Journal of Psychopharmacology, Vol. 9, No. 1,
32-37 (1995) This article has been cited by other articles:
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