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Tolerability of combined treatment with lithium and paroxetine: 19 cases treated under open conditions

Consultant in Psychological Medicine, Queen Elizabeth Hospital, Howlands, Welwyn Garden City, Hertfordshire AL7 4QH

A.G. Roberts

Academic Department of Psychiatry, St Mary's Hospital Medical School, Praed Street, Paddington, London W2 1NY, UK

M.H. Walker

Academic Department of Psychiatry, St Mary's Hospital Medical School, Praed Street, Paddington, London W2 1NY, UK

Nineteen patients resistant to paroxetine monotherapy were treated by lithium augmentation for 6 weeks to assess tolerability. Although the addition of lithium increased the number of adverse events, none were serious. The combination of lithium and paroxetine is safe enough to warrant further investigation as a treatment for resistant depression.

Key Words: paroxetine • lithium • combination • augmentation • safety

Journal of Psychopharmacology, Vol. 8, No. 4, 266-267 (1994)
DOI: 10.1177/026988119400800412


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