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Journal of Psychopharmacology
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Anti-conflict effect of 5-HT1A agonists in rats: a new model for evaluating anxiolytic-like activity

Martine Hascoët

GIS Médicament, Faculté de Medecine, 44035 Nantes cedex, France

Michel Bourin

GIS Médicament, Faculté de Medecine, 44035 Nantes cedex, France

Kathryn G. Todd

GIS Médicament, Faculté de Medecine, 44035 Nantes cedex, France

Anne Coüetoux du Tertre

GIS Médicament, Faculté de Medecine, 44035 Nantes cedex, France

A new conflict procedure was developed to study the potential anti-punishment effects of 5-HT 1A agonists as compared to diazepam. In this paradigm, the opportunity existed for rats to choose during punished periods between immediate, punished reinforcement and delayed, non-punished reinforcement. The results confirm that, for non-sedative doses (1 mg/kg), diazepam increases the number of punished responses. Furthermore, the present paradigm seems sensitive for the detection of 5-HT1A activity. Buspirone, gepirone, ipsapirone, zalospirone and 8-OH-DPAT increased responding for immediate but punished reinforcement. 1-(2-pyrimidinyl)piperazine, the common metabolite of the azapirones, does not participate in their anti-conflict effect. NAN 190, a 5-HT1A antagonist, was shown to block the 5-HT1A agonists. The findings of the present study suggest that benzodiazepines and 5-HT 1A agonists reduce the capacity to tolerate delays in reward. Abnormality in serotonin systems may be associated with poor impulse control.

Key Words: 5-HT1A agonists • diazepam • conflict paradigm • anxiety • delay of reward • rat

Journal of Psychopharmacology, Vol. 8, No. 4, 227-237 (1994)
DOI: 10.1177/026988119400800406
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