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Journal of Psychopharmacology, Vol. 8, No. 3, 185-186 (1994)
DOI: 10.1177/026988119400800308

Pimozide treatment of a male case with de Clérambault's syndrome and schizophrenia

S.M. Dursun

Department of Psychiatry, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK

V.M. Mathew

Department of Psychiatry, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK

M.A. Reveley

Department of Psychiatry, Faculty of Medicine, University of Leicester, Leicester LE2 7LX, UK

Effective treatment with pimozide of a male patient with secondary de Clérambault's syndrome (DCS) and schizophrenia is reported. There was no evidence of relapse at 24-month follow-up. Pimozide is suggested to be the drug of choice in DCS and may be in other disorders in which symptoms of erotomania are prominent. The unique anti-erotomanic activity of pimozide may be due to its calcium channel antagonist activity, a property which is not shared by the other antipsychotic drugs.

Key Words: de Clerambault's syndrome • schizophrenia • pimozide • calcium channel • case report


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