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Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment

Glaw Unit of Behavioural Psychopharmacology, University of Hertfordshire, College Lane, Hatfield, Herts AL10 9AB

Guy A. Higgins

Glaw Unit of Behavioural Psychopharmacology, University of Hertfordshire, College Lane, Hatfield, Herts AL10 9AB, Pharmacology , Glaxo Research and Development Ltd., Park Road, Ware, Herts SG12 ODP, UK

In the present study we have examined the effect of varying three prepulse parameters (prepulse intensity, prepulse duration, prepulse-pulse interval) on the level of prepulse inhibition (PPI) in Lister hooded, Wistar and Sprague-Dawley rats. The results indicate that each strain showed subtle differences in sensitivity to the prepulse. For instance, Sprague-Dawley and Lister hooded rats showed PPI to prepulses of lower saliency compared to Wistar rats. Optimal prepulse parameters were selected for each strain to examine the effects of apomorphine and phencyclidine on PPI. Further inter-strain differences were noted; apomorphine (0.1-1 mg/kg) increased startle amplitude in Lister hooded and Sprague-Dawley, but not Wistar rats. PPI was attenuated in each strain by apomorphine pretreatment. In a final series of experiments, phencyclidine disrupted PPI in each strain, although with greater potency in the Lister hooded rats. A marked behavioural syndrome was seen at phencyclidine doses that disrupted PPI. It is concluded that rat strain and prepulse parameters are important variables in studying drug effects on PPI.

Key Words: prepulse inhibition • apomorphine • rat • phencyclidine • startle parameters

Journal of Psychopharmacology, Vol. 8, No. 3, 148-156 (1994)
DOI: 10.1177/026988119400800302


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