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A double-blind controlled comparison of fluoxetine and lofepramine in major depressive illness

Department of Psychiatry, University College London, Wolfson Building, Middlesex Hospital, London W1N 8AA

M.T. Abou-Saleh

Department of Psychiatry, Royal Liverpool Hospital, PO Box 147, Liverpool L69 3BX

D.A. Harrison

Lilly Industries Ltd., Dextra Court, Chapel Hill, Basingstoke, Hampshire RG21 2SY, UK

B.L. Nairac

Department of Psychiatry, University College London, Wolfson Building, Middlesex Hospital, London W1N 8AA

D.R.L. Edwards

Department of Psychiatry, University College London, Wolfson Building, Middlesex Hospital, London W1N 8AA

T. Lock

Department of Psychiatry, Royal Liverpool Hospital, PO Box 147, Liverpool L69 3BX

R.A. Burns

Department of Psychiatry, Royal Liverpool Hospital, PO Box 147, Liverpool L69 3BX

C.L.E. Katona

Department of Psychiatry, University College London, Wolfson Building, Middlesex Hospital, London W1N 8AA

One hundred and eighty three patients with DSM-III-R major depressive illness were allocated randomly to treatment with one of two new generation antidepressants, fluoxetine and lofepramine. Both patient groups had significantly lower mean scores on the Hamilton Depression Rating Scale (HDRS) 6 weeks after entry to the trial (p < 0.001), but there were no differences between the groups, either at baseline or after 6 weeks, in total HRDS score or in subscores for anxiety or suicidality. Anticholinergic side effects were commoner with lofepramine; adverse effects were on the whole mild and few patients dropped out because of them. This study does not support previous claims of specific adverse effects of fluoxetine on anxiety and suicidality.

Key Words: fluoxetine • lofepramine • comparison • major depressive illness • SSRI

Journal of Psychopharmacology, Vol. 8, No. 2, 98-103 (1994)
DOI: 10.1177/026988119400800205


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