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Journal of Psychopharmacology
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The effect of temazepam on melatonin secretion and light sensitivity

N.H.P. Allen

Department of Psychiatry, Royal South Hants Hospital, Southampton, Hants SO9 4PE

P.J. Smythe

Department of Clinical Biochemistry, Southampton General Hospital, Southampton, Hants, UK

N. Martin

Department of Psychiatry, Royal South Hants Hospital, Southampton, Hants SO9 4PE

L. Plaskett

Department of Psychiatry, Royal South Hants Hospital, Southampton, Hants SO9 4PE

K. Osola

Department of Psychiatry, Royal South Hants Hospital, Southampton, Hants SO9 4PE

P. Childs

Department of Psychiatry, Royal South Hants Hospital, Southampton, Hants SO9 4PE

C. Thompson

Department of Psychiatry, Royal South Hants Hospital, Southampton, Hants SO9 4PE

Seven healthy male volunteers had their light sensitivity (melatonin suppression) and melatonin phase measured before and after treatment with temazepam (20 mg) for 7 days. Temazepam did not alter the circadian phase of melatonin secretion (the Dim Light Melatonin Onset, the timing of the peak of secretion), the total melatonin secretion nor the sensitivity of melatonin secretion to suppression by full spectrum light. This is an important negative finding which suggests that the short half-life benzodiazepine hypnotic temazepam does not confound tests of light sensitivity or melatonin phase.

Key Words: seasonal affective disorder • benzodiazepine • melatonin • light sensitivity • temazepam • circadian rhythm

Journal of Psychopharmacology, Vol. 8, No. 2, 94-97 (1994)
DOI: 10.1177/026988119400800204
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