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Effect of acute tryptophan depletion on mood and appetite in healthy female volunteers

University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford OX4 4XN, UK

A.E.S. Walsh

University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford OX4 4XN, UK

P. Salkovskis

University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford OX4 4XN, UK

D.A. Laver

University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford OX4 4XN, UK

P.J. Cowen

University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford OX4 4XN, UK

Twelve healthy female subjects received the following three drinks in a double-blind, semi-balanced, cross over design: (a) 50 g of amino acids without L-tryptophan (LTP); (b) 50 g of amino acid with LTP (balanced); (c) plain water. Compared to both the balanced amino acid mixture and plain water, the LTP drink significantly lowered plasma total and free tryptophan at 4.5 h. However, compared to the two control conditions, there was no effect of the LTP drink on subjective ratings of mood or hunger. Similarly, the LTP drink did not alter significantly either total calorie intake or the macronutrient content of a test meal 5 h after drink ingestion.

Key Words: L-tryptophan • appetite • hunger • mood • calories • macronutrient

Journal of Psychopharmacology, Vol. 8, No. 1, 8-13 (1994)
DOI: 10.1177/026988119400800102


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