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Journal of Psychopharmacology, Vol. 7, No. 4, 316-324 (1993)
DOI: 10.1177/026988119300700402
© 1993 British Association for Psychopharmacology

Clomipramine, a better reference drug for panic/agoraphobia. I. Effectiveness comparison with imipramine

Valentim Gentil

LIM-23 Departamento de Psiquiatria, Faculdade de Medicina

Francisco Lotufo-Neto

Instituto de Psiquiatria, Hospital das Clínicas/FMUSP

Laura Andrade

Instituto de Psiquiatria, Hospital das Clínicas/FMUSP

Táki Cordás

Instituto de Psiquiatria, Hospital das Clínicas/FMUSP

Márcio Bernik

Instituto de Psiquiatria, Hospital das Clínicas/FMUSP

Renato Ramos

Instituto de Psiquiatria, Hospital das Clínicas/FMUSP

Lucia Maciel

LIM-23 Departamento de Psiquiatria, Faculdade de Medicina

Ernesto Miyakawa

LIM-23 Departamento de Psiquiatria, Faculdade de Medicina

Clarice Gorenstein

Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil

An 8-week, double-blind, flexible-dose trial comparing low doses of clomipramine (mean=50 mg) with moderate doses of imipramine (mean=113.8 mg and propanteline (active placebo), was carried out in 60 out-patients with panic disorder with or without agoraphobia. Efficacy evaluation included global, anxiety and depression rating scales, and the determination of rates of relapse over up to 10 weeks of single-blind placebo follow-up. Both tricyclics were significantly more effective than propanteline, but clomipramine tended to act faster and more consistently than imipramine on most measures. Given the degree of blindness achieved and the significantly lower doses of clomipramine, this seems a better reference drug than imipramine for clinical trials in panic/agoraphobia.

Key Words: clomipramine • imipramine • panic disorder


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