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Journal of Psychopharmacology
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Further evidence that scopolamine can improve verbal fluency

M.P. Dunne

National Centre for HIV Social Research, University of Queensland

D. Statham

National Centre for HIV Social Research, University of Queensland

B. Raphael

National Centre for HIV Social Research, University of Queensland

R. Kemp

Department of Infectious Diseases, Royal Brisbane Hospital

B. Kelly

Department of Psychiatry, Princess Alexandra Hospital, Queensland, Australia

Scopolamine usually is found to impair various aspects of human cognitive performance. Recently, however, a significant (though modest) improvement in verbal fluency has been reported following scopolamine hydrobromide (0.6 and 1.2 mg p.o.). This study replicated that effect, finding significantly better FAS letter fluency in contrast to poorer performance on other neuropsychological measures following sub cutaneous injection of 0.4 mg scopolamine. Data are discussed in terms of a functional state model of drug action.

Key Words: scopolamine • verbal fluency • semantic memory • retrieval • HIV

Journal of Psychopharmacology, Vol. 7, No. 2, 159-163 (1993)
DOI: 10.1177/026988119300700203


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