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Journal of Psychopharmacology
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Platelet {alpha}2-adrenoreceptors in depression: a critical examination

Fred Grossman

Section on Clinical Pharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892, USA

Husseini K. Manji

Section on Clinical Pharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892, USA

William Z. Potter

Section on Clinical Pharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892, USA

During the past decade, results from radioligand studies comparing platelet {alpha}2-adrenoreceptors in depressed patients and healthy volunteers have been inconsistent, especially when related to the known functional characteristics of these receptors. Despite the availability of radioligands for {alpha}2-adrenoreceptors, inherent methodological problems exist which make data from these studies difficult to interpret. The authors review the overall data from radioligand studies using [3H] clonidine and [3H] yohimbine of platelet {alpha}2-adrenoreceptors in depressed patients and healthy volunteers. Theoretical and methodological issues are critically examined in the light of recent findings. Finally, alternative strategies for studying {alpha} 2-adrenoreceptors in clinical populations are considered.

Key Words: {alpha}2-adrenoreceptors • platelets • depression • radioligand studies • review

Journal of Psychopharmacology, Vol. 7, No. 1 suppl, 4-18 (1993)
DOI: 10.1177/0269881193007001031
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