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Journal of Psychopharmacology, Vol. 7, No. 1, 112-118 (1993)
DOI: 10.1177/026988119300700102

Antidepressant therapy in the physically ill: a therapeutic opportunity for the selective 5-HT re-uptake inhibitors?

Roger Lane

Medical Department, Pfizer Limited, Sandwich, Kent CT13 9NJ, UK

Depression is common in physically ill populations, although it is frequently unrecognized and untreated. Diagnosis and antidepressant treatment are discussed. The side-effect profiles of the selective 5-HT re-uptake inhibitors suggest they may offer new therapeutic opportunities in physically ill patients. Sertraline may be of particular benefit in some patients due to its distinct pharmacological profile and the potential for fewer drug interactions. Further evaluation is necessary to determine the risk-benefit ratio for drugs of this class.

Key Words: somatic • tricyclic antidepressant • 5-HT re-uptake inhibitor • pharmacokinetics • drug interaction • cytochrome P450 II D6


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