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5-HT and physical illness

Academic Sub-Department of Psychological Medicine, North Wales Hospital, Denbigh., Clwyd LL16 5SS, UK

The discovery and clinical evolution of 5-HT re-uptake inhibiting drugs are reviewed. From the widespread distribution of 5-HT in bodily systems and the range of effects and side effects reported, it is concluded that these and other drugs active on the 5-HT system are likely to have beneficial effects on a range of other physical conditions coincident and co-morbid with the affective disorders. Clinical vigilance may therefore be repaid with serendipitous discoveries.

Key Words: 5-HT • SSRI • physical illness • review

Journal of Psychopharmacology, Vol. 7, No. 1, 107-111 (1993)
DOI: 10.1177/026988119300700101


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