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Reduction of dyskinesias and psychiatric disability with clozapine over different time courses

Mercer University School of Medicine, 1550 College Street, Macon, GA 31207

Peter A. LeWitt

Sinai Hospital, 14800 West McNichols, Suite 001, Detroit, MI 48235

Samuel Gershon

Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA

Nine subjects with schizophrenia or schizoaffective disorder were treated with clozapine, 500 mg/day for at least 3 months. Each was affected by tardive dyskinesia whose severity was reduced significantly after 3 months of treatment but not at earlier monthly assessments. In contrast, psychiatric symptoms were lessened significantly after 1 month. The more delayed improvement of dyskinesia as compared to the pace of psychiatric improvement suggests a differential effect of the drug.

Key Words: clozapine • tardive dyskinesia • dosage • AIMS • video assessment • BPRS

Journal of Psychopharmacology, Vol. 6, No. 4, 514-518 (1992)
DOI: 10.1177/026988119200600407


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