This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Best, N.R. Articles by Cowen, P.J. Search for Related Content PubMed Articles by Best, N.R. Articles by Cowen, P.J. Social Bookmarking                         What's this?

Effect of oestradiol treatment on 5-HT and dopamine-mediated neuroendocrine responses

MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, Oxford

M.P. Rees

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK

D.H. Barlow

Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK

P.J. Cowen

MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, Oxford

We assessed the effect of oestradiol treatment in women on the endocrine responses to the 5-hydroxytryptamine (5-HT) precursor, L-tryptophan (LTP) (5 g i.v.) and the dopamine agonist, apomorphine (0.005 mg/kg s.c.). Following oestradiol implant (100 mg s.c.) the prolactin (PRL) response to LTP was significantly enhanced but there was no change in the growth hormone (GH) response to apomorphine. There was, however, a significant correlation between post-implant oestradiol concentrations and post-implant apomorphine-induced GH release. The results indicate that oestrogen treatment may facilitate 5-HT-mediated PRL release and could also influence the regulation of dopamine-mediated GH responses. However, further studies are needed to exclude direct effects of oestradiol on the pituitary release of PRL and GH.

Key Words: oestradiol • 5-hydroxytryptamine • L-tryptophan • apomorphine • prolactin • growth hormone

Journal of Psychopharmacology, Vol. 6, No. 4, 483-488 (1992)
DOI: 10.1177/026988119200600403


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. Wieck, R. A. Davies, A. D. Hirst, N. Brown, A. Papadopoulos, M. N. Marks, S. A. Checkley, R. C. Kumar, and I. C. Campbell Menstrual Cycle Effects on Hypothalamic Dopamine Receptor Function in Women with a History of Puerperal Bipolar Disorder J Psychopharmacol, June 1, 2003; 17(2): 204 - 209. [Abstract] [PDF]