This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Duka, T. Articles by Fichte, K. Search for Related Content PubMed Articles by Duka, T. Articles by Fichte, K. Social Bookmarking                         What's this?

Scopolamine-induced amnesia in humans: lack of effects of the benzodiazepine receptor antagonist ß-carboline ZK 93426

Human Pharmacology, Schering AG, Postfach 65 03 11, D-1000, Berlin 65, Germany

Volker Edelmann

Human Pharmacology, Schering AG, Postfach 65 03 11, D-1000, Berlin 65, Germany

Barbara Schütt

Human Pharmacology, Schering AG, Postfach 65 03 11, D-1000, Berlin 65, Germany

Rainer Dorow

Human Pharmacology, Schering AG, Postfach 65 03 11, D-1000, Berlin 65, Germany

Klaus Fichte

Human Pharmacology, Schering AG, Postfach 65 03 11, D-1000, Berlin 65, Germany

It has been suggested from pharmacological studies in animals that ZK 93426 may improve memory and other cognitive processes in humans. Scopolamine has been used to model aspects of memory impairment. To test the effects of ZK 93426 alone and in combination with scopolamine, ZK 93426 (0.04 mg/kg) or vehicle (Intralipid R) was administered intravenously (i.v.) to normal controls, pre-treated with either scopolamine 0.5 mg administered subcutaneously (s.c.) or the same volume of saline. A visual (presentation of pictures) and a verbal (words list) memory test were applied. Both drugs on their own and in combination were found to be safe and well tolerated. ZK 93426 did not antagonize the scopolamine-induced impairment of acquisition of the words list. Scopolamine did not impair delayed recall of visual or verbal material. ZK 93426 alone improved performance in delayed recall of visual material presented after drug application, whereas it impaired performance in delayed recall of visual material presented before drug administration.

Key Words: ZK 93426 • scopolamine • amnesia • memory tests

Journal of Psychopharmacology, Vol. 6, No. 3, 382-388 (1992)
DOI: 10.1177/026988119200600307


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?