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Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress

Department of Psychology, City of London Polytechnic, Old Castle St., London E1 7NT, UK

Spiros Lappas

Department of Psychology, City of London Polytechnic, Old Castle St., London E1 7NT, UK

Richard Muscat

Department of Psychology, City of London Polytechnic, Old Castle St., London E1 7NT, UK

Paul Willner

Department of Psychology, City of London Polytechnic, Old Castle St., London E1 7NT, UK

Chronic exposure to very mild unpredictable stress has previously been found to reduce or abolish the acquisition of place preference conditioning. In the present study, chronic mild stress was found to abolish the acquisition of preferences for a distinctive environment paired with morphine (0.7 mg/kg). However, chronic mild stress did not impair the acquisition of place aversion conditioning induced by naloxone (0.7 mg/kg) or picrotoxin (2.0 mg/kg). The results demonstrate that chronic stress does not cause a general impairment of associative learning but, rather, a specific impairment of rewarded behaviour.

Key Words: stress • place conditioning • morphine • naloxone • picrotoxin • rats

Journal of Psychopharmacology, Vol. 6, No. 3, 352-356 (1992)
DOI: 10.1177/026988119200600302


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