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Memory functions, alertness and mood of long-term benzodiazepine users: a preliminary investigation of the effects of a normal daily dose

Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK

The effects of a normal daytime dose of a benzodiazepine (BZ) on memory functions and mood were assessed in 20 out-patients who had taken BZs regularly for an average of 10 years. The results implied that these chronic users may have developed tolerance differentially to the sedative, anxiolytic and amnesic effects of one dose of BZ. A daytime dose did not produce subjective sedation. Lack of change in psychomotor performance and certain memory measures may either show tolerance or imply that the drug counteracts a possible practice effect. Anxiety levels decreased markedly after a daily dose, but this does not necessarily imply a purely pharmacological effect. Memory impairments were apparent in terms of increased susceptibility to proactive interference. This impairment was significantly correlated with the dosage of BZ taken.

Key Words: memory • mood • sedation • benzodiazepines • long-term use

Journal of Psychopharmacology, Vol. 6, No. 1, 69-75 (1992)
DOI: 10.1177/026988119200600113


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