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Journal of Psychopharmacology
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Effects of zinc gluconate and nedocromil sodium on performance deficits produced by the common cold

A.P. Smith

Health Psychology Research Unit, School of Psychology, University of Wales College of Cardiff, PO Box 901, Cardiff CF1 3YG

D.A.J. Tyrrell

MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wiltshire SP2 8BW

W. Al-Nakib

MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wiltshire SP2 8BW

I. Barrow

MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wiltshire SP2 8BW

P. Higgins

MRC Common Cold Unit, Harvard Hospital, Coombe Road, Salisbury, Wiltshire SP2 8BW

R. Wenham

Fisons PLC, Pharmaceutical Division, Loughborough, UK

Two studies are reported on the effects of drugs on the performance impairments induced by experimentally- produced colds. The first study examined the effects of zinc gluconate on choice reaction time, and showed that the zinc removed the cold-induced performance impairment. The second experiment used nedocromil sodium and, again, the drug was effective in reducing the drop in performance observed in volunteers with colds. While the precise mode of action of these compounds is unclear it is speculated that one mechanism involves changes in trigeminal stimulation, and this could be responsible for both the clinical efficacy and CNS effects of these drugs.

Journal of Psychopharmacology, Vol. 5, No. 3, 251-254 (1991)
DOI: 10.1177/026988119100500312
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