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Bromocriptine requires D-1 receptor stimulation for the expression of sniffing behaviour in ratsDepartment of Pharmacology, Medical Faculty, University of Tehran, Iran
Department of Pharmacology, Medical Faculty, University of Tehran, Iran
The effect of the mixed D-1/D-2 dopamine agonist apomorphine, the D-2 agonist bromocriptine and the D- 1-selective dopamine agonist SKF 38393 on sniffing behaviour in rats was tested in the present experiments. Apomorphine induced a dose-dependent sniffing, which was decreased by either D-2 or D-1 dopamine antagonist pre-treatment. Atropine (antimuscarinic drug) or phenoxybenzamine and propranolol (
Journal of Psychopharmacology, Vol. 5, No. 2,
160-165 (1991) |
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and ß- adrenergic blockers, respectively) did not alter the apomorphine response. Apomorphine induced a significant increase in sniffing in reserpine-treated animals. Bromocriptine produced sniffing during the 3rd hour after drug injection. The effect was decreased by sulpiride or SCH 23390 pre-treatment. Phenoxybenzamine or propranolol did not change the bromocriptine effect, while atropine increased the drug response. SKF 38393 also induced a slight but significant sniffing. In rats pre-treated with reserpine, neither bromocriptine nor the D-1-selective agonist SKF 38393 produced any sniffing. However, the combination of bromocriptine with SKF 38393 produced an intense sniffing behaviour. It may be concluded that bromocriptine requires D-1 receptor stimulation for the expression of sniffing.