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Differential effect of lithium treatment on fenfluramine-induced decreases in food intake and locomotor activity in rats

Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health

J. Zohar

Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health

K.M. Wozniak

Laboratory of Clanical Studies, National Institute of Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA

J.L. Hill

Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health

D.L. Murphy

Section on Clinical Neuropharmacology, Laboratory of Clanacal Science, National Institute of Mental Health

Administration of fenfluramine to rats decreased 1-h food intake and locomotor activity. Short-term (2-6 days) but not long-term (21-25 days) lithium treatment potentiated fenfluramine-induced suppression of food intake. However, neither short-term nor long-term lithium treatment had any significant effect on fenfluramine-induced suppression of locomotor activity. These findings demonstrate a differential effect of lithium treatment on fenfluramine-induced suppression of food intake and locomotor activity. Furthermore, these findings are consistent with results from several other animal and clinical studies demonstrating a differential effect of lithium treatment on two different serotonin-mediated functions.

Journal of Psychopharmacology, Vol. 5, No. 2, 149-154 (1991)
DOI: 10.1177/026988119100500209


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