This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Panickar, K. S. Articles by McNaughton, N. Search for Related Content PubMed Articles by Panickar, K. S. Articles by McNaughton, N. Social Bookmarking                   What's this?

Dose-response analysis of the effects of buspirone on rearing in rats

Department of Psychology and Centre for Neuroscience, University of Otago, Dunedin, New Zealand

Neil McNaughton

Department of Psychology and Centre for Neuroscience, University of Otago, Dunedin, New Zealand

The effects of buspirone were tested on rearing in an open field. Six different doses of buspirone (10, 3.3, 1.1, 0.3, 0.1 and 0.04 mg/kg) and a single dose of chlordiazepoxide (5 mg/kg) were administered i.p. to separate groups of rats. Buspirone produced a dose-dependent decrease in rearing in the range 0.04-10 mg/kg, whereas only the higher doses (10 and 3.3 mg/kg) decreased ambulation significantly. Chlordiazepoxide reduced rearing to an extent equivalent to 1 mg/kg of buspirone. Together with data in the literature, the results suggest that 5-HT1A agonists affect rearing at lower doses than ambulation; that the effects of buspirone in the open field are similar to classical anxiolytics; and that changes in rearing may be more closely related to anxiolytic than muscle relaxant, anti-convulsant and other GABA-mediated effects of the classical anxiolytics.

Journal of Psychopharmacology, Vol. 5, No. 1, 72-76 (1991)
DOI: 10.1177/026988119100500110


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				X.-o. Zhu and N. McNaughton Similar effects of buspirone and chlordiazepoxide on a fixed interval schedule with long-term, low-dose administration J Psychopharmacol, January 1, 1995; 9(4): 326 - 330. [Abstract] [PDF]