This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Wesnes, K. Articles by Christmas, L. Search for Related Content PubMed Articles by Wesnes, K. Articles by Christmas, L. Social Bookmarking                         What's this?

The use of a scopolamine model to study the potential nootropic effects of aniracetam and piracetam in healthy volunteers

Cognitive Drug Research, 13 The Grove, Reading RG1 4RB, UK

R. Anand

F. Hoffmann-La Roche Ltd, CH-4002 Basle, Switzerland

P. Simpson

Cognitive Drug Research, 13 The Grove, Reading RG1 4RB, UK

L. Christmas

Cognitive Drug Research, 13 The Grove, Reading RG1 4RB, UK

In this study 26 healthy volunteers received scopolamine 0.7 mg subcutaneously on seven occasions at least a week apart. Cognitive efficiency was measured with a test battery before and 60 min following scopolamine on each occasion. Following this, over the seven occasions, a range of oral and intravenous dose regimens were administered including aniracetam 2 mg intravenously, 100 mg intravenously, 200 mg intravenously, 1500 mg per os and piracetam 2400 mg per os. On each session the test battery was then performed again at 120 and 200 min following scopolamine. The seven treatments were administered double- blind and the order was counterbalanced between volunteers over visits using a Latin Square design. At 60 min, scopolamine produced marked and significant decrements in all of the measures of memory and information processing. Aniracetam 1500 mg was able to sig nificantly antagonize decrements on both memory and information processing tasks. The other active treatments also produced significant effects, but for two these were equal to, and for two slightly above, the number which may have occurred by chance, and thus were questionable. Overall, the findings demonstrate that aniracetam 1500 mg can antagonize cognitive decrements produced by cholinergic blockade in healthy volunteers, and suggest that the drug possesses nootropic properties.

Journal of Psychopharmacology, Vol. 4, No. 4, 219-232 (1990)
DOI: 10.1177/026988119000400406


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?