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Repeated treatment with antidepressant drugs and/or electroconvulsive shock (ECS) does not affect the quinpirole-induced elevation of the serum corticosterone concentration in rats

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland

B. Budziszewska

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland

E. Blaszczynska

Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland

The selective dopamine D2 receptor agonist quinpirole (0.03-1 mg/kg intra peritoneally) increased dose-dependently the serum corticosterone level in rats. The effect of the maximum dose of quinpirole (0.3 mg/kg intraperitoneally) was antagonized in a dose- dependent manner by the selective D2 receptor antagonist sulpiride (3-30 mg/kg intra peritoneally), but not by the selective D₁ receptor antagonist SCH-23390 (3 mg/kg intra peritoneally). Imipramine and amitriptyline (10 mg/kg per os), administered acutely or repeatedly (twice daily for 14 days), did not affect the corticosterone response to quinpirole (0.1 mg/kg intraperitoneally). The response was modified neither in animals treated repeatedly with electroconvulsive shock (ECS) (seven shocks every 2 days), nor after their combined repeated treatment with imipramine and ECS. The above results indicate that repeated treatment with antidepressant drugs and/or ECS does not affect the sensitivity of dopamine D2 receptors involved in the corticosterone response to quinpirole.

Journal of Psychopharmacology, Vol. 4, No. 4, 198-203 (1990)
DOI: 10.1177/026988119000400403


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